Experiments by Kim et al. It also caused an increase in the abundance of ENaC channels. While these results are specific to Li-induced renal effects, they may at least partially explain how a thiazide can serve to decrease polyuria in patients with diabetes insipidus. Lisa Cohen water metabolism Previous Post Hawaii and Population Management Next Post From acid to nephrocalcinosis to stones 5 comments Marcelin December 30, at am In Diabetes insipidus which leads to dilute urine more water loss than salt. Less water has been reabsorbed through the distal renal tubules and collecting ducts water permeability decreased… while Na reabsorption through the Distal Renal tubules and Collecting ducts is normal so it gets back easily to the bloodstream.
Desmopressin will be ineffective in nephrogenic DI which is treated by reversing the underlying cause if possible and replacing the free water deficit. Nephrogenic diabetes insipidus. Effect of hydrochlorothiazide on renal electrolyte gradient in glucose diuresis and experimental diabetes insipidus. Proposed mechanisms of action The following mechanism has been proposed to account for the effect of thiazides in this condition [ 6, 8 ].
Volume Read Later Share. A thiazide diuretic, such as chlorthalidone or hydrochlorothiazide, can be used to create mild hypovolemia which encourages salt and water uptake in proximal tubule and thus improve nephrogenic diabetes insipidus. The main effector organ for fluid homeostasis is the kidney. J Clin Invest. A comparison of the effects of adrenalectomy and of chlorothiazide in experimental diabetes insipidus. With increased thirst, the person now experiences a polydipsia and polyuria cycle. Pediatrics in Review. Sign In.
Bendz H, Aurell M. J Small Anim Pract. Drinking sufficient fluids . Proc R Soc Med. Because less water and solute depleted, however, the body will retain water at the expense of deranging electrolyte levels. When the volume is severely.